PRSS1 (Protease, serine 1) encodes cationic trypsinogen
An inactive precursor of trypsin.
PRSS 1 Gene On Chromosome 7 at position 7q35
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PRSS1 Gain Of Function Missense Mutation
Pancreatitis = Pancreatic Cancer
Snapshot
PRSS1 mutation → Chronic pancreatitis → Repeated injury → Genetic mutations accumulate → Pancreatic cancer



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