Necroptosis

 

                                                                             Necroptosis  

 

 

 

 

Discovery Of Necroptosis 

 

A major breakthrough occurred in 2005, when Alexei Degterev and colleagues, working with Junying Yuan, described a small molecule called Necrostatin-1. This compound inhibited a specific type of necrotic cell death. Crucially, they showed that the process was regulated rather than accidental, and linked it to a kinase called RIPK1. This study effectively established necroptosis as a distinct, programmed pathway. 

 

 

 

 

 

 Necroptosis

 

 

 

 

Mechanism Of Necroptosis

 

 

 

 

 

Apoptosis VS Necroptosis 

 

 

 

Necroptosis In Pathology

 

 

 

 

 

Pathology: Ischemic Reperfusion Injury (Necroptosis) 

 

 

 

 

Snapshot

 

 

 

 

 

 

 

 

 

 

 

 

 

FISH

 

                                                                                 FISH

                                                        Fluoroescence In Situ Hybridization 

1986–1988: David Pinkel and colleagues demonstrated modern FISH techniques.

They showed that fluorescent probes could accurately bind chromosomal DNA

 

 

 

 FISH

 

Detect abnormalities in DNA  

 

 

 

 

 

 

 

 

 

 Theory To Application 

 

 

 

 

 Snapshot

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Smile Surgery

                                       

 

                                                                                Eyes  

                                                                     SMILE Surgery For Eyes 

 

 

 

 SMILE Surgery

 

Small Incision Lenticule Extraction 

 

 

 

 

 

 

 

 SMILE Surgery

 

Minimally Invasive Vision Correction 

 

 

 

 

 

FDA Approved Indications For SMILE Surgery

  

 

 

SMILE VS LASIK
 

 

 

 

Smile Incision 

 

 

 

 

 

 

 

Snapshot

 

 

 

 

 

 

 

 

 

 

 

 

 

                                   

                  

                                    

Sly Syndrome

 

 

                                                                                  Sly  

                                   Deceiving People In A Clever Way To Get What You Want  

 

 

 

 Fox are Sly

 

 

 

 

 

 

Sly To Sly Syndrome 

 

Dr William Sly = Sly Syndrome 

 

 

 

 

Sly Syndrome 

 

 

 Mepsevii: Enzyme Replacement Therapy For Sly Syndrome 

 

 

 

 

 

 

 

Snapshot

 

 

 

 

 

 

 

 

 

 

 

 

 

Dr Alois Alzheimer

                                                                    Dr Alois Alzheimer

 

 

Alzheimers Disease Found On Autopsy

 

 

 

Alzheimers  Disease

                        Neurofibrillary tangles had been observed  by Alois Alzheimer.

 

 

 

 

 

 

In the 1980s, scientists demonstrated that these tangles were composed of abnormally aggregated tau protein.

                                                            

 

                                                                     Tau Protein  

 

 

 

 

 

 

Snapshot