In 1948, Asherman published a detailed description of women who developed:
Amenorrhea
Infertility
Recurrent pregnancy loss after dilatation and curettage (D&C) procedures.
Alanine
The earliest successful synthesis of an amino acid is credited to Adolph Strecker in 1850.
This reaction demonstrated that amino acids could be formed from simple chemical precursors (aldehydes, ammonia, hydrogen cyanide).
Adolph Strecker
Strecker Synthesis = Alanine
A non-essential amino acid (humans can synthesize it)
A key participant in metabolism, especially the glucose–alanine cycle
It became clear that alanine plays roles in:
Nitrogen transport
Energy metabolism
Protein structure
Theory To Practice
Alanine derivatives are linked to carnosine metabolism, though:
Beta-alanine:
✔ Increases carnosine levels
✔ Buffers muscle acidity
✔ Has strong evidence for performance benefits
The Book Of Job In The Holy Bible
Job syndrome was first described in 1966 by Davis, Schaller, and Wedgwood.
They reported children with a striking clinical triad:
Recurrent “cold” staphylococcal abscesses (lacking typical inflammation)
Severe eczema-like dermatitis
Recurrent pulmonary infections
Because the skin lesions resembled the boils suffered by Job, the condition was named Job syndrome.
Pantothenic acid was identified in 1931 by Roger J. Williams, an American biochemist who isolated the compound while studying yeast growth factors. Williams observed that yeast required a specific substance for proper growth, which he later purified and named pantothenic acid. The name comes from the Greek word “pantothen”, meaning “from everywhere
Yeast needs pantothenic acid for growth
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Grierson–Gopalan syndrome is a clinical entity historically described in India, characterized primarily by burning sensations of the feet, often accompanied by paresthesias (tingling, numbness).
The syndrome is named after:
Philip Grierson – who reported cases of unexplained burning feet among prisoners in colonial India.
C. Gopalan – a pioneering Indian physician–nutritionist who later studied the condition extensively.
Grierson first described the phenomenon in the early 20th century, noting prisoners complaining of intense burning pain in their feet without obvious structural disease.
Gopalan's works on Indian foods also are commendable. He analysed over 500 Indian foods for their nutritive values and published a detailed study report of that. This work was used for calculating dietary in-take of all nutrients. This made India the first developing country to have its own recommended dietary allowances.
Under his leadership, India developed:
Recommended Dietary Allowances (RDAs)
National nutrition surveys
Scientific food policies: Midday meal concepts Child nutrition strategies
