Sixth Disease

 

                                                          Historical Names Of Disease

 

 

 

 Sixth Disease

 

Human Herpes Virus 6 = Sixth Disease  

 

Human Herpes Virus 6 And Multiple Sclerosis

 

 

Recent studies report that in MS patients the serological response against HHV-6A is increased whereas it is decreased against HHV-6B. This effect seems to be even more pronounced in MS patients prior to diagnosis and supports previous studies postulating a predomination for HHV-6A in MS disease and suggests that the infection is important at early stages of the disease. Furthermore, HHV-6A infection interacts with other factors suspected of modulating MS susceptibility and progression such as infection with Epstein-Barr virus (EBV) and Cytomegalovirus (CMV), tobacco smoking, HLA alleles, UV irradiation and vitamin D levels. 

 

 

                                                                    Snapshot

 

 

 

           

 

 

 

 

 

 

 

 

Necroptosis

 

                                                                             Necroptosis  

 

 

 

 

Discovery Of Necroptosis 

 

A major breakthrough occurred in 2005, when Alexei Degterev and colleagues, working with Junying Yuan, described a small molecule called Necrostatin-1. This compound inhibited a specific type of necrotic cell death. Crucially, they showed that the process was regulated rather than accidental, and linked it to a kinase called RIPK1. This study effectively established necroptosis as a distinct, programmed pathway. 

 

 

 

 

 

 Necroptosis

 

 

 

 

Mechanism Of Necroptosis

 

 

 

 

 

Apoptosis VS Necroptosis 

 

 

 

Necroptosis In Pathology

 

 

 

 

 

Pathology: Ischemic Reperfusion Injury (Necroptosis) 

 

 

 

 

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FISH

 

                                                                                 FISH

                                                        Fluoroescence In Situ Hybridization 

1986–1988: David Pinkel and colleagues demonstrated modern FISH techniques.

They showed that fluorescent probes could accurately bind chromosomal DNA

 

 

 

 FISH

 

Detect abnormalities in DNA  

 

 

 

 

 

 

 

 

 

 Theory To Application 

 

 

 

 

 Snapshot

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Smile Surgery

                                       

 

                                                                                Eyes  

                                                                     SMILE Surgery For Eyes 

 

 

 

 SMILE Surgery

 

Small Incision Lenticule Extraction 

 

 

 

 

 

 

 

 SMILE Surgery

 

Minimally Invasive Vision Correction 

 

 

 

 

 

FDA Approved Indications For SMILE Surgery

  

 

 

SMILE VS LASIK
 

 

 

 

Smile Incision 

 

 

 

 

 

 

 

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Sly Syndrome

 

 

                                                                                  Sly  

                                   Deceiving People In A Clever Way To Get What You Want  

 

 

 

 Fox are Sly

 

 

 

 

 

 

Sly To Sly Syndrome 

 

Dr William Sly = Sly Syndrome 

 

 

 

 

Sly Syndrome 

 

 

 Mepsevii: Enzyme Replacement Therapy For Sly Syndrome 

 

 

 

 

 

 

 

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