EXAMS AND ME

Wednesday, 28 October 2026

Journavx

Sodium Channels

Vertex Pharmaceuticals

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Suzetrigine

Suzetrigine aka Journavx

Selective NaV 1.8 Sodium Channel Inhibitor

Approved January 30, 2025

Mechanism Of Action

NaV Channels And Pain

Mechanism Of Action

Inhibitor Of NaV Channels Causing Pain

Theory To Practice

Journavx

Journavx VS Novocaine

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Blast From The Past: Statue Of Liberty

October 28, 1886

Statue Of Liberty Was Unveiled

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Harley Quinn is a fictional character from DC Comics who evolved from the Joker's comic sidekick into one of the most recognizable antiheroes in modern comics. Her real name is Dr. Harleen Frances Quinzel, a former psychiatrist at Arkham Asylum in Gotham City.

Creators: Paul Dini and Bruce Timm.

First appearance: September 1992, in the episode Joker's Favor of Batman: The Animated Series.

Original voice actress: Arleen Sorkin.

Harley was initially designed as a minor character who would appear in just one episode. Her popularity led the creators to develop her into a recurring character.

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Estrogen

History Of Estrogen

Emil Knauer

Emil Knauer’s pioneering paper on ovarian transplantation, published in 1896, was the first to scientifically prove that transplanting an ovary could prevent the symptoms of castration (menopause) and maintain uterine function.

Titled "Einiges über Ovarien-Transplantation" (Notes on Ovarian Transplantation) and published in the Centralblatt für Gynäkologie, his work laid the foundational groundwork for modern reproductive endocrinology and tissue preservation.

Allen and Doisy Experiment

The Allen and Doisy experiment was a landmark experiment in endocrinology that demonstrated the existence of a hormone produced by the ovaries, now known as estrogen.

It helped establish that ovarian hormones regulate the female reproductive cycle and produce characteristic changes in the reproductive tract.

Adolf Butenandt: Advanced the chemical isolation and characterization of crystalline estrogen.

1933 — Emmenin

James Collip and colleagues developed Emmenin, an estrogen preparation derived from the urine of pregnant women, making hormone treatment commercially available.

1941–1942 — Synthetic estrogen and Premarin

The US FDA approved diethylstilbestrol (DES) in 1941. Conjugated equine estrogens, marketed as Premarin, were introduced for menopausal symptoms in 1942. Premarin's name derives from pregnant mares' urine.