MRI In Acromegaly

1984 – Bernard Kaufman

Published Magnetic Resonance Imaging of the Pituitary Gland in Radiologic Clinics.

 

1986 – Glaser and colleagues

Published Magnetic Resonance Imaging of the Pituitary Gland in Clinical Radiology.

Their study included 22 patients with pituitary disease and 17 controls. They demonstrated that MRI could identify large pituitary tumours and assess their parasellar and suprasellar extension.

 

 

 

 1981: Gd-DTPA was described as a potential MRI contrast agent.

1983: First human administration took place in Berlin on 10 November.

1984: Carr and colleagues published the initial clinical experience in 20 patients.

 

 

1988: Magnevist received FDA approval on 28 June.

 

 

 Contrast-enhanced MRI improved the localization of pituitary microadenomas. 

 

 

 

 

 

 

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Oral Glucose Tolerance Test In Acromegaly

                                                                      Acromegaly

                                 Oral Glucose Tolerance Test In Diagnosis Of Acromegaly

 

 

 

 

Diagnosis Of Acromegaly 

 

Use Of OGTT In Acromegaly

 

 

 

 

 

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Pegvisomant

  

                                                                          Acromegaly 

1997: Research by Peter J. Kopchick and colleagues helped establish the potential of growth hormone receptor antagonism.

 

 

 

 

 2000: Clinical development demonstrated that pegvisomant could effectively reduce circulating IGF-1 in patients with acromegaly.

 2002: Approved by the US FDA for treatment of acromegaly.

 

 

 

 

 

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Jack-o'-Lantern

 

10,000 years ago: Early pumpkin domestication in the Americas

~8,000 BCE: Archaeological evidence of cultivated pumpkin

1492 onwards:  European contact with American crops

16th century:  Pumpkin introduced into European agriculture

1640s:  Word pumpkin recorded in English

17th century: Pumpkin pie documented in English-language cooking

19th century onwards:  Pumpkin becomes a major symbol of American autumn traditions

The Jack-o'-Lantern is one of the most recognisable symbols of Halloween. Its history combines ancient Celtic traditions, Irish folklore, Christian festivals and the arrival of European immigrants in North America.

The most famous explanation of the Jack-o'-Lantern comes from an Irish folktale about a man called Stingy Jack.

According to the legend:

1. Jack invited the Devil for a drink but did not want to pay.

2. He persuaded the Devil to transform himself into a silver coin.

3. Jack trapped the coin beside a silver cross, preventing the Devil from changing back.

4. Later, Jack tricked the Devil again by trapping him in a tree.

5. Jack eventually died, but neither Heaven nor Hell accepted him.

6. The Devil gave Jack a burning coal to illuminate his eternal wandering.

7. Jack placed the coal inside a hollowed-out turnip.

                                                  

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Intestinal Obstruction Caused By Roundworms

 

                                                                   Human Roundworm

Bowel Obstruction Can Be Caused By Roundworms

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