Neuroblastoma

 

In 1891, American pathologist James Homer Wright described a childhood adrenal tumor with characteristic circular cell arrangements now called Homer Wright rosettes.

 James Homer Wright proposed that these tumors arose from primitive sympathetic nerve cells (neuroblasts).

                                            James Homer Wright = Homer Wright Rosettes 

 

 

 

 Neuroblastome 

 

Cancer that arises from neural crest cells  

 

 

  Chromosomal abnormalities found in neuroblastoma 

• In the 1980s, amplification of the MYCN gene was discovered.

MYCN amplification became:

• Marker of aggressive disease
• Important prognostic factor  

• 1p deletion/17q gain/ALK mutation

   

  

 

 

 

MYCN And Tumour Biology 

 

 

 

 

 

 

Snapshot