Difficilis

                                            Difficilis (Difficult)

Difficilis

is a Latin adjective meaning "difficult," "hard," "troublesome," or "hard to manage/please".

In 1935, Ivan C. Hall and Elizabeth O’Toole isolated a new anaerobic bacterium from the stool of healthy newborn infants.

They named it Bacillus difficilis because it was difficult to isolate and culture. 

 

  

 

 

 In the 1970s, work by John G. Bartlett and colleagues showed: Patients with antibiotic-associated colitis had a cytotoxin in stool. The toxin was produced by Clostridium difficile

 In 1978, this established C. difficile as the cause of pseudomembranous colitis / difficile colitis.

 

 

 

 

 Antibiotics Used For Treatment

 

 

 

 

Fidaxomicin 

 

In the early 1980s, researchers at Abbott Laboratories were searching for new antibiotics from soil microbes.

 A soil sample collected in Hamden, Connecticut yielded a new microorganism:

• Dactylosporangium aurantiacum subspecies hamdenensis

  This organism produced a new macrolide compound later called tiacumicin, which became fidaxomicin.

 

 

 

 

 

Fidaaxomicin

 

 

 

 

 

 

Current Events

 

THE WHOLE WORLD SAYS YES TO THINGS WHICH WORK 

 

EVEN IF IT IS DIFFICULT TO BELIEVE  

International Yes Day refers to a book written by Amy Krouse Rosenthal, recently popularized by the movie 'Yes Day' starring Jennifer Garden and Edgar Ramirez.

 International Yes Day is an informal celebration observed every year on March 12

 

 

 

 

 

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