Phospholamban

 

 

 

• In 1975, Arnold M. Katz and colleagues identified this protein as a regulator of calcium transport
• It was named “phospholamban”:
  • “phospho” → phosphorylation-dependent
  • “lamban” → from Greek lambanein (“to receive” or “to take up”), referring to calcium uptake

---

Phospholamban (PLN) is a small but very important regulatory protein in cardiac muscle cells, especially involved in controlling calcium handling and heart contractility. 

 

 

 

 

 Phospholamban Is A Protein That Regulates Ca ATPase In Sarcoplasmic Reticulum 

 

 

 

 

 

Inotropy = Phosphorylation Of Phospholamban 

 

 

  

 

 

Snapshot 

 

Phospholamban is considered one of the key regulatory proteins in cardiac physiology, because its discovery:

• Linked β-adrenergic signaling to calcium handling
• Provided a molecular explanation for changes in heart contractility