Gottfried Ritter von Rittershain,
1878: Gottfried Ritter von Rittershain, a
German physician, first described the condition in neonates. He studied over 300
infants in a Vienna foundling hospital and identified a distinct syndrome
of skin blistering and peeling that resembled burns.
This led to the early
term: "Ritter’s disease."
1956 –
Identification of Staphylococcal Cause
The causative link between Staphylococcus aureus and exfoliative skin disease was made in the mid-20th century.
1960s–1970s – Toxin
Elucidation
Researchers discovered
exfoliative toxins A and B (ETA and ETB), secreted by certain strains of
S. aureus, as the pathogenic agents causing the skin peeling.
These toxins were found to target desmoglein-1, a cadherin protein in the skin's desmosomes, leading to superficial epidermal cleavage.
.jpg)
.jpeg)
No comments:
Post a Comment