Langerhans Cell

                                                                    Paul Langerhans

Paul Langerhans In University Of Berlin 

1868 – Paul Langerhans

The German medical student Paul Langerhans first described these cells in his doctoral thesis at the University of Berlin.

• He observed special dendritic-shaped cells in the epidermis using a gold chloride staining method.
• At the time, he thought they were part of the nervous system, since their dendritic projections resembled nerve cells.

Langerhans Cells - Skin 

1940s–1950s

The immune role began to be suspected. Electron microscopy revealed Birbeck granules (rod- or racket-shaped organelles unique to Langerhans cells), distinguishing them from other skin cells.

 

                                           BECK GRANULES = LANGERHANS CELLS

1960s–1970s

Experiments by Ralph Steinman and Zanvil Cohn (who discovered dendritic cells in 1973) clarified that Langerhans cells were not neurons but rather antigen-presenting immune cells.

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