IgE

                                            Kimishige Ishizaka and Teruko Ishizaka

                              Husband And Wife Discovered Immunoglobulin E 

Kimishige Ishizaka and Teruko Ishizaka, working at the Children's Asthma Research Institute and Hospital in Denver, Colorado, were the first to isolate and identify IgE.

They published their discovery in 1967, showing that this new class of immunoglobulin was responsible for triggering allergic responses.

 

Scientific Importance of IgE

Physiological Role: Plays a role in immune defense against helminths and other parasites.

Pathological Role: Central to the pathogenesis of type I hypersensitivity reactions, such as:

Allergic rhinitis

Asthma

Atopic dermatitis

Anaphylaxis

IgE = Released In Exposure To Allergen

Allergens = Release Of  IgE 

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