Chronic Myeloid Leukemia is a blood stem cell disorder caused by the BCR-ABL fusion gene, resulting from the Philadelphia chromosome
1983 – Philadelphia Chromosome & BCR-ABL
Discovery of the Philadelphia chromosome (Ph chromosome) in chronic myeloid leukemia (CML).
Found that the BCR-ABL fusion gene produces a constitutively active tyrosine kinase, driving uncontrolled proliferation of white blood cells.
Early 1990s – Rational Drug Design
Dr. Nicholas Lydon and team at Ciba-Geigy (now Novartis) designed STI-571, later called Imatinib, to inhibit BCR-ABL tyrosine kinase specifically.
Current Events
World CML Day is observed every year on 22nd September. It is dedicated to raising awareness about Chronic Myeloid Leukemia (CML), a type of blood cancer.
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