Gomori Methenamine Silver Stain

 

Gomori’s Work (1930s–1940s):

• George Gomori developed several silver-based stains (e.g., Gomori’s Methenamine Silver stain for basement membranes in 1946).

• His methods laid the foundation for applying methenamine silver to microorganisms.

  Grocott’s Modification (1955):

• R.H. Grocott, an American pathologist, modified Gomori’s technique specifically to improve fungal visualization in tissue sections.

• Published in the American Journal of Clinical Pathology (1955), his method became the standard GMS stain used in medical mycology

   

   

                                                           Black Yeast Cells
  

  BLACK
  
   

   

   

   

   
  

  Snapshot