Gomori Methenamine Silver Stain

 

Gomori’s Work (1930s–1940s):

• George Gomori developed several silver-based stains (e.g., Gomori’s Methenamine Silver stain for basement membranes in 1946).

• His methods laid the foundation for applying methenamine silver to microorganisms.

  Grocott’s Modification (1955):

• R.H. Grocott, an American pathologist, modified Gomori’s technique specifically to improve fungal visualization in tissue sections.

• Published in the American Journal of Clinical Pathology (1955), his method became the standard GMS stain used in medical mycology

   

   

                                                           Black Yeast Cells
  

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Cardiac Poison

 

                                                                         Cardiac Poison  

 

 

 

 Aconite 

 

Toxicity: One of the most poisonous plants known; contains alkaloids like aconitine, which are potent neurotoxins and cardiotoxins.

Mechanism: Aconitine binds to voltage-gated sodium channels in nerves and cardiac tissue, keeping them open → persistent depolarization → arrhythmias, paralysis, and death.

 

 

 

 

 

 

Poisonings Throughout History: George Henry Lansom

Lamson was put on trial for murder in March 1882 and was found guilty based on evidence that he purchased the poison – aconite

 

 

 

 

 

 

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An Account of the Foxglove and Some of Its Medical Uses

      William Withering (1785), an English physician, published

      “An Account of the Foxglove and Some of Its Medical Uses”.

• He observed that extracts of foxglove reduced edema in patients with heart failure (then called “dropsy”).

• Withering’s work is considered the birth of modern pharmacology, since he carefully documented dosing, effects, and toxicity.

 

 

 

 

 

 

Foxgloves To Digoxin 

 

 

 Uses Of Digoxin

 

 

 

 

 

Digoxin Toxicity

 

 

 

 

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World Heart Day

 

                                                              Cardiac Conduction System 

 

 

 

 

 Jan Evangelista Purkinje

 

Czech anatomist, Jan Evangelista Purkinje, identified networks of fibres composed of grey, flat, gelatinous cells that contained tightly packed nuclei in the ventricular sub-endocardium of sheep hearts  

 

 

 

 

Dr Wilhelm His, Jr,

 

 Wilhelm His, Jr, a Swiss anatomist, searched to see what connected the atria and ventricles, and in 1893, he recorded a description of the conducting bridge that was later be known as the bundle of His: “I have succeeded in finding a muscle bundle which unites the auricular and ventricular septal walls …

 

 

 

 

 Sunao Tawara, a Japanese pathologist working in the laboratory of Ludwig Aschoff, meticulously examined the AV junction, including the AV bundle, through histology on serial tissue sections

 

 

 

 

 

Arthur Keith (1866–1955) – a Scottish anatomist and anthropologist, well known for his work on human evolution and comparative anatomy.

 

 Martin Flack (1882–1931) – a British physiologist and anatomist, who collaborated with Keith during his early career.

 

 

 

Conduction System Of Heart
 

 

 

 

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Bunlde Of His

 

                                                             Cardiac Conduction System

 

 

 

 

 

 Dr Wilhelm His Jr

 

The Bundle of His is named after Wilhelm His Jr. (1863–1934), a Swiss anatomist and cardiologist, who first described it in 1893.

He first described the atrioventricular bundle (Bundle of His) in 1893 in his paper “Die Tätigkeit des embryonalen Herzens und deren Bedeutung für die Lehre von der Herzbewegung beim Erwachsenen”.

 

 

 

 

 

 

 

Bundle Of His 

 

 

 

Action Potential Of Heart
 

 

 

 

 

 

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