Lipodystrophy refers to a group of disorders characterized by loss (partial or complete) of adipose tissue, often associated with metabolic abnormalities.
Early Description (19th Century)
- First clearly described by Mitchell Henry in 1885
- Reported patients with:
- Marked loss of body fat
- Prominent musculature
- Initially considered a rare constitutional disorder
- 1885 – Mitchell Henry: first description
- 1906–1911 – Barraquer & Simons: partial lipodystrophy
- 1954–1959 – Berardinelli & Seip: congenital generalized form
- 1990s – HIV-associated lipodystrophy recognized
- 2000s – Genetic and hormonal basis established
Liodystrophy = Leptin Deficiency
Leptin For Lipodystrophy
Approved by U.S. Food and Drug Administration in 2014 for generalized lipodystrophy
“Metreleptin, a recombinant leptin analog, is used to treat generalized lipodystrophy by improving insulin resistance, hypertriglyceridemia, and fatty liver.”
Current Events
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