Wunderlich Syndrome

 

 

  

 

Wunderlich syndrome  =  Spontaneous renal hemorrhage without trauma

Bleeding may occur into:

• Renal parenchyma
• Subcapsular space
• Perirenal space
• Retroperitoneum

Most common cause

• Renal angiomyolipoma (AML)

Abnormal vessels → aneurysm → rupture → bleeding → retroperitoneal hematoma

 Classic triad = flank pain + mass + shock

 

 

 

 

 

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Clinical Thermometer

 

 

 

 

 

 

Carl Wunderlich: Clinical Thermometer 

 

Wunderlich is famous for proving that:

• Body temperature varies with disease
• Fever patterns help diagnose illness

He collected >1 million temperature readings from ~25,000 patients.

His book:

• Das Verhalten der Eigenwärme in Krankheiten (1868)
  → “The Course of Temperature in Diseases”

He established:

• Normal body temperature ≈ 37 °C (98.6 °F)

This became a standard in medicine worldwide

 

 

 

 

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Lynch Syndrome

 

 

 

 

 In 1895, pathologist Aldred Scott Warthin at the University of Michigan described a family with multiple cases of:

• colon cancer, endometrial cancer and gastric cancer. 

 

The syndrome was rediscovered by Henry T. Lynch, an oncologist and geneticist.

• In the 1960s, Lynch studied families with: 
• early-onset colon cancer
• multiple cancers across generations
• no polyposis (unlike FAP)  

 

 

 

 

 

 

Lynch Syndrome And Genetics

 

 

 

 

 

Current Events

 

 

 

 

 

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