P Glycoprotein

                                                             P-Glycoprotein Structure

  P Glycoprotein

Pumps Drugs Out Of Cell

Distribution Of P Glycoprotein 

Efflux pump: P-gp actively transports a wide range of substances out of cells using energy from ATP hydrolysis.

                                  

                                          Physiological Roles

Tissue	Function of P-gp
Intestine	Limits oral absorption of drugs by pumping them back into lumen
Liver	Promotes drug excretion into bile
Kidney	Enhances drug excretion into urine
Blood-brain barrier	Prevents entry of drugs/toxins into the CNS
Placenta	Protects fetus by limiting drug transfer

 

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