Arias Stella Reaction

 

Dr. Jorge Arias-Stella, a Peruvian pathologist, who first described the phenomenon in the 1950s in relation to abnormal endometrial changes during pregnancy.

The Arias-Stella reaction is a benign, non-neoplastic change seen in the endometrial glands of the uterus. It is a hormone-induced cellular response, primarily due to elevated progesterone levels, typically during pregnancy or with hormonal stimulation (e.g., from oral contraceptives or certain tumors).

                                  Non Neoplastic Changes In Endometrial Glands Of Uterus 

                                                  Hormone Induced Cellular Response 

                                        Elevated Progesterone Levels During Pregnancy

                                                   Can Be Seen In Certain Tumors 

                               

              

                                  

The endometrial glands show:

• Hyperchromatic, enlarged nuclei

• Nuclear atypia (can resemble malignancy)

• Irregular nuclear contours

• Increased mitotic activity is absent

• Cytoplasmic vacuolization

• Decidualized stroma may be present

Snapshot 

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