Herbert Durham Reaction

                                           

The Gruber–Durham reaction refers to the bacterial agglutination reaction discovered independently by Max von Gruber and Herbert Edward Durham in 1896.

• Max von Gruber (Austrian bacteriologist) and Herbert Edward Durham (British bacteriologist) demonstrated that the serum of an animal immunized against a particular bacterium could cause visible clumping (agglutination) of that bacterium.
• Their work provided one of the earliest demonstrations of a specific antigen–antibody reaction.
• The reaction became an important basis for serological diagnosis and bacterial identification.

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