Portuguese neurologist Mário Corino da Costa Andrade first observed patients in northern Portugal, particularly among fishing communities in Póvoa de Varzim, who complained of a regional condition locals called “mal dos pesinhos” (foot disease). Fishermen specifically noticed a dangerous loss of temperature and pain sensitivity in their feet when handling fishing ropes.
Andrade formally described the disease as the first form of hereditary amyloidosis in the medical journal Brain, naming it Familial Amyloidotic Polyneuropathy (FAP).
Corino de Andrade's disease, better known as Familial Amyloid Polyneuropathy (FAP) or hereditary transthyretin amyloidosis (hATTR), is a rare, fatal genetic neurodegenerative disease. It is characterized by the progressive buildup of abnormal amyloid proteins that damage nerves and organs
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