Sliding Filament Theory

 

In the 1940s, Albert Szent-Györgyi and coworkers showed that ATP provides energy for muscle contraction and identified the interaction between actin and myosin 

 

 

 

 

 

  

Birth of the Sliding Filament Theory (1954)

The modern theory was established on 22 May 1954, when two landmark papers were published in Nature.

Two independent research groups reached similar conclusions:

1. Andrew F. Huxley and Rolf Niedergerke
2. Hugh E. Huxley and Jean Hanson 

In 1957, Hugh E. Huxley provided electron microscopy evidence showing overlapping thick and thin filaments.

 

 

 

Sliding Filament Theory

 

 

 

 

 

 

Skeletal Muscle Physiology

 

Nobel Prize Physiology/Medicine, 1963

 

 

  

 

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