1857 – Thomas Addison & William Gull (London)
First described a form of “chronic intrahepatic cholangitis”, recognizing inflammation and sclerosis of bile ducts during autopsy.
1970 – Ludwig, Wiesner, and LaRusso (Mayo Clinic, USA)
Provided the modern clinicopathologic definition of PSC as a chronic cholestatic disease of unknown etiology, distinct from secondary causes (e.g., stones, infection, surgery).
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