1949 – Discovery of Succinylcholine:
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Ernest H. Bovet (Switzerland/Italy) and Daniel Bovet (Italian pharmacologist, Nobel laureate 1957) and colleagues at the Institut Pasteur, France, were studying choline esters for pharmacological activity.
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They synthesized succinylcholine (two acetylcholine molecules linked by a succinic acid bridge).
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It was found to produce temporary muscle paralysis similar to curare but with a very short duration of action.
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