Monday 18 June 2018

Potency


Camphor: Strong Aromatic Odour On Burning 

Camphors burns without leaving ash or residue


Camphor: Solid ketone obtained from volatile oil of Cinnamomum Camphora


Camphor: Physical Degradation



Camphor Degradation: Loss Of Volatile Components 

Volatile contents lost at ambient temperature through vaporization

Volatile Components are present in 

Alcohol, Ether, Iodine, Volatile Oils, Camphor and Menthol



Loss Of Volatile Components Depends Solely On Potency



Potency: Amount Of Drug required to produce a response

Pure Natural Extracts are more potent than diluted extracts

Thick Cream more potent in flavour in comparison to diluted butter milk



Examples


Pain Killers

10 mg of Piroxicam is more potent than 100 mg of Aspirin 


Carfentanil is more potent than Heroin



Clobetsol Propionate (0.05): Superpotent Steroid



Cannabis has got 300 % stronger in 30 years



Pharmaceutical Degradation Affects The Potency Of The Drug


Physical Degradation

Example:  Vitamin Tablets

Expired Vitamin Tablets/Capsules = Change In Drug Release

Expired Vitamin Tablets dont have the expected content in them


Other Preparations

Expired Suspension: Loss Of Drug Content Uniformity


Expired Emulsions: Loss of drug content uniformity in doses


Expired Oinments: Loss of drug content uniformity



Apart From Physical There Is Chemical Degradation


Microbial Degradation


Pharmaceuticals

Short term application/effects




Snapshot










































No comments:

Post a Comment