Adams Oliver Syndrome

 

 

Notch Pathway Mutations 

 

 

 

 

 

Adams Oliver Syndrome 

 

Adams–Oliver Syndrome was first described in 1945 by Dr. Forrest H. Adams and Dr. Clarence Paul Oliver, two American physicians.

• They reported eight family members across three generations with:

  • Congenital scalp defects (aplasia cutis congenita)

  • Terminal transverse limb defects

• The inheritance pattern suggested autosomal dominant transmission.

• This original report established AOS as a distinct congenital malformation syndrome.

  
  

   
   
   
   
  Current Events
   
   

  

  
  
  
  
                                                                              Snapshot