Saturday 10 September 2022

Quinolinic Acid

 

                                                                          Tryptophan


 
 
 
 
                                  Tryptophan: Serotonin Pathway and Kynurenine Pathway

 
 
 
 
Serotonin Pathway 
 

 
 
 
Tryptophan To Serotonin To Melatonin
 

 

 
 



95 % of Tryptophan Metabolism: Kynurenine
 
 
 
Kynurenine Pathway 
 
 

 
 
Kyneurric Acid: Neuroprotective
 

 

 
 
Quinolinic Acid: Neurotoxic
 
 

 

Quinolinic Acid Increase: Motor neuron Damage/Death


 
 
 
 
Lead Increases Quinolinic Acid  
 
 
 
 
 
High Cortisol/Pro Inflammatory Cytokines: Increase Quinolinic Acid
 
 
 
 
 
 
Snapshot
 
 





 




 

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