Stylograph

Stylograph: Fountain Pen 

Stylographic Pen: Ink Pen

Stylographic Pen

History Of Stylograph 

Petrache Poenaru: Inventor Of The Fountain Pen

Progress in developing a reliable pen was slow until mid 19 th century

Petrache Poenaru designed a Fountain Pen with a replaceable cartilage 

French Government issued a patent on Worlds First Ink Pen in May 25, 1827 

Founder of the Ink Pen also  designed the Flag Of Romania

1827 To 1884

Practical Version of the Fountain pen was produced in 1884 by American Inventor

L.E Waterman

Watermans Fountain Pen Since 1884

Waterman followed by

Improvements since the Fountain Pen

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Denigrate

Denigrate: To attack someones character/Put Down

Denigrate: Neecha Dikhana 

Word In Context

Word In Current Events

            Critics accuse Fox of allowing language that fuels antisemitism

Fox News is facing growing criticism and calls for a boycott amid accusations that language used on its programming is fueling antisemitism, prejudice and violence.

The network has even banned a guest who used incendiary language to link billionaire George Soros to the migrant caravan.

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                                             Denigrate: You idiot degenerate

Chediak Higashi Syndrome

Proteins can move between compartments in different ways 

Proteins that exit the Golgi Apparatus: 3 Destinations

Signal mediated diversion to Lysosome via Endosome

Constitutive secretory pathway

Regulated secretion pathway

Lysosome

Lysosome: Garbage disposals for the cell digesting and recycling cellular waste 

Chediak Higashi Syndrome (Cuban and Japanese Physicians)

Abnormal intracellular protein transport

Defect in Lysosomal traffic regulator gene (LYST 1 gene)

Chediak Higashi (Intracellular Accumlations)

Abnormal protein transport

Abnormal intracellular protein transport: Infections/Albinism/Bleeding

Death before the age of 10

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Gunter Blobel

Protein Synthesis

1. Synthesis of a polypeptide chain from amino acid that occurs on Ribosomes

Synthesis of polypeptide chain takes place with participation of mRNA and tRNA

2. Post translational modification of polypeptide chain 

Protein Synthesis To Protein Sorting 

Protein Sorting: Gunter Blobel Signalling amino acid sequence

Proteins have intrinsic signals that govern their transport and localization of cell

Proteins govern their transport to golgi complex and secretory vacuoles

Proteins govern their transport and exocytose

Protein Secretory Pathway

Synthesis To Exocytosis

Nobel Prize and Proteins

First Nobel Prize in Medicine: Antitoxin

Von Behring developed Antitoxin to treat Diphtheria 

Diptheria Antitoxin: Refined and Concentrated Proteins

Protein Antitoxin To Protein Sorting 

Protein Sorting 1999

Signal Hypothesis

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Gunter Blobel: Pioneer Of Molecular Biology