Pelizaeus Merzbacher Disease

 

                                                  Described clinically by Pelizaeus in 1885

                                                Described clinically by Merxbacher in 1910

                                                 Role Of Proteolipid Protein  - 1964

X Linked Recessive 

PLP 1 Gene Mutation = Axonal Demyelination

MRI 

Tigroid Pattern Is Seen On MRI 

Tigroid Pattern Seen On MRI 

Snapshot