Hyper IgM Syndrome

 

 

 

 

 

 

 

The first inference of IgM was made in 1937 in horses immunized with pneumococcus polysaccharide. The vaccine-induced anticarbohydrate antibodies were shown to be 3–4 times larger than γ-globulins (Heidelberger & Pedersen, 1937).

 

 Immunoglobulin (M) (IgM) was first characterized in 1944 via immunoelectrophoresis and ultracentrifugation by Waldenström, Pederson, and Kunkel from patients with B cell lymphoma (WALDENSTRÖM, 1944) (Wallenius, Trautman, Kunkel, & Franklin, 1957).  In these experiments, highly elevated concentrations of IgM were visualized. Originally named macroglobulin, it was not until the 1960’s when the nomenclature for Ig-isotypes was developed, that macroglobulin became the “M” in IgM (Black, 1997; Cohen, 1965; R Ceppellini, 1964).

 

 

 

                                            IgM First Characterised In 1944 By Waldenstrom  

 

 

 

 

 

 

 

 Waldenstroms Macroglobulinemia To IgM

 

 

 

 

 

 

 

 Class Switching 

IgM To IgG, IgG, IgG, IgA and IgE

 

 

 

 

 

 

Hyper IgM Syndrome 

 

 

 

 

 

 

 Snapshot