Hirudins

  

                                                                      Hirudo Medicinalis

                                       

 

 

 

 

Hirudin is a Leech Extract

 

 

 

 

 

 

Hirudin aka Medicinal Leeches 

 

 

 

 

 

 

 

 

History

 

 

1957: Markwardt isolated the active anticoagulant  

 

65 Amino Acids Polypeptide which inhibits Thrombin 

 

 

Anticoagulants
 

 

 

 

 

 

 

Direct Thrombin Inhibitors  

 

The First DTI was Lepirudin

 

Lepirudin is a polypeptide that binds directly to active site of Thrombin

 

 

 

Lepirudin 

 

 

 

 

 

 Direct Thrombin Inhibitor

 

 

 

 

 

 

 

 Thrombex aka Lepirudin 

 

 

 

Snapshot