Melanocortin System

                                                                    Melanocortin System

                                                      Pro - Opiomelanocortin Gene (POMC)

                Release of alpha/beta/gamma MSH (Melanocyte Stimulating Hormone)

                      Alpha/Beta/Gamma MSH acts on MCR 1,2,3,4,5 receptors

Alpha MSH 

Alpha MSH neurons acts on the Melanocortin 4 receptor

Activation Of Melanocortin 4 receptor suppresses Apetite 

It increases metabolism of Fat and Lean Body Mass

Leptin Hormone acts on the the Melanocortin 4 receptor by activating alpha MSH

Increased activation of MCR 4 receptor 

Buproprion and Naltrexone activates the MCR-4 Receptor

Snapshot

Alpha MSH (Anorexigenic)