Christmas Disease

                                                                                Blood

 

 

 

 

 

 

Clotting Factors Present In Plasma

 

 

 

 

 

Liver: Indirect Role In Clotting 

 

 Coagulation Factors Synthesized By Liver

 

 

 

 Clotting Cascade

 

 

Factor 9 aka Christmas Factor

 

 

 

 

Factor 9 Deficiency = Christmas Disease

Christmas disease is named after Stephen Christmas, the first known person to be diagnosed with the condition (Healthline). After being hospitalized, Rosemary Biggs and R.G. Macfarlane, experts at Oxford’s Haemophilia Centre, noticed something peculiar about Stephen. They noticed that he had no deficiency in Factor VIII which is seen in Hemophilia A patients. Unlike those with Hemophilia A, Stephen had a deficiency in Factor IX (Medical History Tour). Blood coagulation tests were conducted and he was diagnosed with Christmas disease in 1952. The British Medical Journal first described Christmas disease in their December 27, 1952 issue (Medical History Tour). At first many people thought the described disease was some kind of joke because of the name and the date of publication.

 

 

 

 

 

 

 

 

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