Henry Bowditch
Bowditch inserted a glass
cannula into the atrium of a dissected frog heart, extending it into the
upper third of the ventricle and securing it in place. An additional
cannula was inserted into the ventricle and connected to a mercury
manometer. The heart’s apex was electrically stimulated, allowing for
the observation of frequency and amplitude of contractions via an
oscilloscope. This led to the discovery of the “Treppe” effect. The
Treppe phenomenon, also known as the staircase phenomenon or
frequency-dependent activation, suggests that an elevation in heart rate
enhances the contractile force of myocardial cells with each successive
heartbeat, independent of other factors
The Staircase Effect (Bowditch Effect)
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