Proguanil

 

                                                                               Proguanil

 

 

 

 

Proguanil and an analog of atovaquone were first identified as potential antimalarial agents during the U.S. Army’s drug discovery and development program during World War II

 

When the Japanese attack on Pearl Harbor started World War II in the Pacific, the US became very interested in antimalarials and funded a large joint US-UK program to find new non-toxic and easy to produce drugs of the type.

 

It was joined by a team led by Frank Rose at the Medical Chemicals Section of Imperial Chemical Industries

 

 Proguanil was approved in 1948 by FDA for use in humans as an antimalarial agent, but it was not widely used. In the 1950s the first reports of Plasmodium parasite resistance to proguanil when taken as monotherapy occurred

 

 Proguanil continues to be used in other countries in combination with other antimalarial agents, such as chloroquine, for malaria prophylaxis. 

                                                                Proguanil Prophylaxis

 

 

                                                               Mechanism Of Action

 

 

 

 

 

 

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