The antidiuretic property of Vasopressin was discovered a century ago in 1913, by reputed Italian scientist F. Farini in Venice and well-known German researcher von den Velden in Dusseldorf, who worked independently on investigating hormonal actions in the human system.
In 1927 - 1928, renowned American chemist Oliver Kamm successfully isolated and purified both oxytocin and vasopressin from bovine pituitary extracts.
During the period from 1951 to 1953. Vincent du Vigneaud, an established American biochemist, successfully determined the structure of arginine vasopressin (AVP) to be a sequence of nine amino acids. He also was the first researcher to chemically synthesize vasopressin in the laboratory in 1954. For his pioneering work on delineating the hormonal structure and function of both polypeptides - oxytocin and vasopressin,
Vincent du Vigneaud was awarded the prestigious Nobel Prize In Chemistry in the year 1955.
Vasopressin
Vasopressin is a polypeptide hormone, with the structure of arginine vasopressin being a sequence of nine amino acids i.e. a nonapeptide - Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2. The chemical structure of vasopressin is similar to that of oxytocin, also a peptide hormone secreted by the pituitary gland.
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