Alfred Kohn And Chromaffin Cells
Chromaffin cells owe their name to the color produced by a chemical reaction of adrenaline. In the 19th century it was found that an unidentified substance in the adrenal medulla reacts with ferric chloride to produce a greenish color and with chromium salts to produce a yellowish brown. At the beginning of this century Alfred Kohn, working in Prague, coined the term chromaffin for cells stained by chromium. At about the same time adrenaline, the cellular compound responsible for the reaction, was isolated and synthesized in the laboratory
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CHROMAFFIN REACTION yields a yellowish brown color, it takes place when chromium salts applied to adrenal tissue react with oxidized adrenaline in the chromaffin cells. In this micrograph of rat adrenal gland the color distinguishes the adrenal medulla, the site of the chromaffin cells, from the blue-stained adrenal cortex: the part of the adrenal gland that surrounds the medulla. The oval space corresponds to the central vein, which carries off secretions.
Adrenal Medulla = Adrenaline
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