Langerhans

Paul Langerhans To Langerhans Cells

Bone marrow derived Antigen presenting cells in middle of epidermis

Langerhans Cell: Capture antigen and display them to T cell

Expresses MHC 2, CD 1a and Langerin 

Birbeck Granules (Tennis Racket) in cytoplasm of Langerhans is characteristic

Langerhans cell discovered in 1868

Langerhans Cell is associated with Histiocytosis X in 1973 

Histiocytosis X 

Hand Schuller Christian (1893)

Letterer Siwe disease (1924)

Spectrum of Histiocytosis X (1953)

Diagnosis: Biopsy shows Racquet cells on Electron Microscopy

Snapshot

Langerhans Cell

Langerhans Cell To Histiocytosis X