Chediak Higashi Syndrome

Proteins can move between compartments in different ways 

Proteins that exit the Golgi Apparatus: 3 Destinations

Signal mediated diversion to Lysosome via Endosome

Constitutive secretory pathway

Regulated secretion pathway

Lysosome

Lysosome: Garbage disposals for the cell digesting and recycling cellular waste 

Chediak Higashi Syndrome (Cuban and Japanese Physicians)

Abnormal intracellular protein transport

Defect in Lysosomal traffic regulator gene (LYST 1 gene)

Chediak Higashi (Intracellular Accumlations)

Abnormal protein transport

Abnormal intracellular protein transport: Infections/Albinism/Bleeding

Death before the age of 10

Snapshot

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