B12 Absorption

 

Vitamin B12 And Intrinsic Factor 

Work by Rosenberg, Herbert, and others pointed to the existence of a large intestinal receptor responsible for binding IF–B12, but its molecular identity remained unknown.

• Intrinsic Factor, secreted by gastric parietal cells, binds to vitamin B₁₂ (cobalamin) in the stomach.

• The IF–B₁₂ complex is essential for B₁₂ absorption in the terminal ileum.

• Without this complex, B₁₂ cannot be absorbed effectively.

Vit B12 - Intrinsic Factor Complex Absorbed By Cubulin Receptors In Ileum 

Snapshot