Somatostatin
Discovered in the Hypothalamus in 1973 by Brazeau and Guillemin
Somatostatin is a naturally occurring inhibitory polypeptide hormone first isolated from the sheep hypothalamus (Brazeau et al., 1973).
It is widely distributed throughout the human central nervous system (CNS) and peripheral tissues.
Somatostatin has a broad range of biological actions that include the regulation of neurotransmission and secretion and the inhibition of the release of growth hormone (GH), thyroid-stimulating hormone (TSH), gastrointestinal (GI) hormones, pancreatic enzymes and neuropeptides (Lamberts, 1988; Schettini, 1991).
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