Urokinase

 

                                                                       Human Kidney

Kidney Cells: Glomerulus 

Urokinase 

First Described In 1951

Urokinase, a plasminogen activating proteolytic enzyme, was first described in 1951 as occurring in trace quantities in mammalian urine. 

The urokinase detected in urine is produced by kidney cells. It has been reported that the urokinase secreted by kidney cells is antigenically similar to the one isolated from urine.

 Urokinase catalyzes the conversion of plasminogen to plasmin

All characterized commercial preparations of urokinase contain one or both of these enzymatically active forms. 

The major source of commercially available urokinase is human urine 

Mechanism Of Urokinase

Theory To Practice 

Snapshot