Philanthotoxin

 

 

 Beewolf paralyzing its prey

 

 

Beewolf To Philanthotoxin 433 

 

PhTX-433 was structurally elucidated and synthesized in 1988 by Eldefrawi and colleagues. For the isolation and structural identification of PhTX-433 female wasp venom glands were fractionated

 

 

 

 

 

 

Philanthotoxin 433 

 

Philanthotoxins reversibly inhibit AMPA (also called the "quisqualate receptor"), kainate, and NMDA ionotropic glutamate receptors (iGluRs)

 

 

 

 

 

 

Philanthotoxin: Block Nicotinic Acetylcholine  Receptors

 

 

 

 

 

 

Snapshot 

 

 

Philanthotoxin: Glutamate Antagonist