800,000 DNA modification event per cell per day
Unrepaired DNA: Cancer
Repaired DNA: No Cancer
Nobel Prize: DNA Repair Mechanism
Example: Mismatch Repair Mechanism
Mismatch repair markers: MSH2, MLH1, MSH6, PMS2, PMS1
Gene Products in Mismatch Repair
(hMLH1/hMSH2/hMSH3/hMSH6)
(hPMS and hPMS2)
Mismatch Repair (DNA repair in E Coli)
Gene products in Mismatch repair mutated in HNPCC (Lynch Syndrome)
E Coli To Human Model
Lynch Syndrome Model
Mutation in mismatch repair genes: Tumorigenesis
Lynch Syndrome
Model to Real World Cancer Dynamics
Similarly Failure in the spectrum of DNA repair mechanism lead to
Big C
Cancer
Cancer Therapy deals with tumour suppression and no repair mechanism
Writer Doctors
Siddharta Mukherjee talks about Cancer
Pulitzer Prize for writing the Biography Of Cancer
Siddhartha Mukherjee on Cancer
Ancient connection between Cancer and Depression
Positive attitude does not cure any Cancer
Cancers are alike in a unique way
Medicine: Hope is not absolute. It is not that simple
Pharmacology is benefited by the prepared mind
Most discoveries today are a combination of serendipity and of searching
Making Happy Discoveries whilst looking for other things
Serendipity
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