Each gene has a distinct biological effect
Polygenic Trait
Many genes contribute to a single effect
Polygenic trait: Responsible for slight and variable range of differences throughout population
Disease Status
Polygenic Score: Determines Your Genetic Risk
Combining several markers across the genome leads to Polygenic risk scores
Example: Myocardial Infarction (Monogenic Vs Polygenic)
Monogenic Mutation
Polygenic Mutation
High Polygenic Score = High risk for MI
Polygenic Risk and Adult Obesity
Intelligence
Genetic and Environmental factors contribute to intelligence
Cognitive abilities are polygenic measured by many genes
Intelligence is Polygenic
People with many SNP related to academic achievement
Higher polygenic score= Higher academic achievement
Lower polygenic score= Lower academic achievement
Can Genes Tell Your Future
Genetic Data can predict height, intelligence, personality and disease
Type 2 DM is influenced by atleast 400 locations in our DNA
Scientist can now assign Polygenic score based on thousands of genes
Polygenic Scores are like report card predicting future diseases
Polygenic Score (DNA Fortune Telling)
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