Animals Can Produce Vitamin C In The Body
Most animals can produce Vitamin C (ascorbic acid) in the liver from glucose. The final step of this pathway requires the enzyme:
L-gulonolactone oxidase (GULO)
Humans Cannot Synthesize Vitamin C In The Body
Humans lack a functional GULO enzyme because the GULO gene is mutated and inactive (a pseudogene). The mutation occurred about 40–60 million years ago in a common ancestor of primates. Since their diet was rich in fruits (high in Vitamin C), there was no evolutionary pressure to maintain the enzyme.
Humans Have To Obtain Vitamin C From Food


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