Alport Syndrome

 

                                                             History Of Alport Syndrome 

Dr Cecil Alport = Alport Syndrome 

Interestingly, Dr Alport initially believed the etiology of the disorder was an individual susceptibility to a toxin of an unknown organism, probably belonging to the streptococcal group.

The pathogenesis of the disorder known as Alport syndrome remained unknown until early 1970’s, when advances in electron microscopy allowed the identification of characteristic abnormalities in GBMs.

Alport Syndrome 

Pathophysiology

Electron Microscopy - Basement Membrane Damage 

Mutations In Type 4 Collagen Family

Alport Syndrome 

Snapshot