Quinolinic Acid

 

                                                                          Tryptophan

 

 

 

 

 

 

                                  Tryptophan: Serotonin Pathway and Kynurenine Pathway

 

 

 

 

 

Serotonin Pathway 

 

 

 

 

 

Tryptophan To Serotonin To Melatonin

 

 

 

 

95 % of Tryptophan Metabolism: Kynurenine

 

 

 

 

Kynurenine Pathway 

 

 

 

 

Kyneurric Acid: Neuroprotective

 

 

 

 

Quinolinic Acid: Neurotoxic

 

 

 

Quinolinic Acid Increase: Motor neuron Damage/Death

 

 

 

 

Lead Increases Quinolinic Acid  

 

 

 

 

 

 

 

High Cortisol/Pro Inflammatory Cytokines: Increase Quinolinic Acid
 

 

 

 

 

 

 

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