Stem Cell To Foregut ToPancreas
Development Of Pancreas
Pancreas develops from 2 buds (Ventral/Dorsal Pancreatic Duct)
It arises from the endoderm of the caudal part of Foregut
Development Of Pancreatic Ducts
Pancreas:History
Herophilus: Greek anatomist first described Pancreas around 300 BC
Herophilos
1 st known use of Human Cadavers
Herophilos To Wirsung
Duct Of Wirsung was discovered by Johann Georg Wirsung in the 16 th century
Murder and Medicine (Human Anatomy)
Johann Georg Wirsung was supposedly murdered by his Comptitors
His Competitors were jealous about his achievement
𝗣𝗮𝗻𝗰𝗿𝗲𝗮𝘁𝗶𝗰 𝗱𝘂𝗰𝘁 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗺𝘂𝗿𝗱𝗲𝗿 𝗺𝘆𝘀𝘁𝗲𝗿𝘆
The pancreatic duct that joins the pancreas to the common bile duct was discovered in 1642 by anatomist Johann Wirsung during the dissection of a man who had been recently hanged for murder. The duct is also called the "duct of Wirsung" in his honor. Instead of publishing his finding, Wirsung engraved a sketch of the duct on a copper plate, from which he made 7 imprints, and subsequently had them delivered to 7 leading anatomists throughout Europe. Wirsung was shot and killed while chatting with his neighbors near his home. Reportedly it was the result of an argument as to who was the discoverer of the pancreatic duct and many conflicting stories about the identity of the assassin exist .
Wirsung’s mentor, the anatomist Johann Wesling, was accused of the crime because he was said to be jealous of Wirsung’s discovery. Moritz Hoffmann, the medical student who assisted Wirsung in dissection, was another suspect. He claimed to have discovered the duct of the pancreas in a turkey a year before Wirsung’s human dissection; he also claimed to have informed Wirsung of this finding. The most likely suspect was Giacomo Cambier. Just a week before the assassination, Cambier had been forced to resign his position as Procurator of the German Nation of Artists due to “doubts about his character,” and Wirsung was involved with the decision process.
𝑺𝒐𝒖𝒓𝒄𝒆 Bassi C, Malleo G. The unsolved mystery of Johann Georg Wirsung and of (his?) pancreatic duct. Surgery. 2011 Jan;149(1):153-5.
The World Keeps Moving
People Keep On Discovering New Things
The World Still Stays The Same
336 BC Till Date
- Pancreas was first discovered by Herophilus, a Greek anatomist and surgeon (born in 336 BC).
- Four hundred years later, Ruphos, in the 1st or 2nd Century AD, an anatomist–surgeon of Ephesus, gave the name ‘pancreas’. Writing in Greek, the word meant ‘all flesh’.
- Johann Georg Wirsüng, a German émigré, discovered the pancreatic duct in Italy, in 1642, thereby initiating the study of the pancreas.
- Pancreas as a secretory organ was investigated by Reignier de Graaf, a 22 year old student of Leiden, Netherlands in 1671.
- D. Moyse, a student in Paris, was the first to describe the histology of the pancreas in his thesis of 1852.
- Paul Langerhans, a student at Berlin Institute of Pathology, described the islets of the pancreas in his thesis of 1869, which were subsequently to be known as the ‘islets of Langerhans’
- In 1889, Joseph F. von Mering and Oskar Minkowski of Strasbourg proved that total pancreatectomy (in the dog) resulted in diabetes.
- In 1921, at the University of Toronto, Frederick Grant Banting, a young orthopedic surgeon, and Charles Herbert Best, a medical student, discovered insulin. The digestive enzymes (amylase, lipase, trypsin, etc) were discovered in the mid to late 19th century.
- It was not until 1927, almost 35 years after the discovery of x-rays by Wilhelm Conrad Röentgen on November 8, 1895 (Würzburg, Germany), that an abdominal x-ray study first proved diagnostic of pancreatic disease (pancreatic calculi). Radiologic imaging of the pancreas was to become an essential step in the diagnosis of pancreatic disease....
In 1958, Frederick Sanger of England was awarded the Nobel Prize in Chemistry for the determination of the molecular structure of insulin.
Herophilus 300 BC
Snapshot
Duct Of Wirsung 16 th Century
Black and White World (Old World)
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